Polymeric nanosphere

S. Stainmesse, A. M. Orecchioni, and E. Nakache, Modelling of an original process to obtain biocompatible polymeric nanospheres, in 1992 6th International Conference on Pharmaceutical Technology, pp. 89-97. 

Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R (1994) Biodegradable long-circulating polymeric nanospheres. Science 263 1600-1603. 

Li Z, Ding J, Day M, Tao Y. Molecularly imprinted polymeric nanospheres by diblock copolymer self-assembly. Macromolecules 2006 39 2629-2636. 

A polymeric nanosphere may be defined as a matrixtype, solid colloidal particle in which drugs are dissolved, entrapped, encapsulated, chemically bound or adsorbed to the constituent polymer matrix. These particles are typically larger than micelles having diameters between 100 and 200 nm and may also display considerably more polydispersity (Fig. 3.21). 

Cen L, Neoh KG, Kang ET (2005) Gold nanocrystal formation on viologen-fimctionalized polymeric nanospheres. Adv Mater 17 1656-1661... 

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V., and Langer, R. (1994), Biodegradable long-circulating polymeric nanospheres, Science, 263, 1600-1603. 

Langer R. Biodegradable long-circulating polymeric nanospheres. Science 1994 263 1600-1603. 

Cohen-Sacks H, et al. (2002). Novel PDGFbetaR antisense encapsulated in polymeric nanospheres for the treatment of restenosis. Gene Ther. 9 1607-1616. 

Lee, K. E., Kim B. K., and Yuk S. H. 2002. Biodegradable polymeric nanospheres formed by temperature-induced phase transition in a mixture of poly(lactide-co-glycolide) and polyfethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer. Biomacromolecules 3 1115-1119. 

Of late, significant interest has been paid to hollow polymeric nanostructures (HPNSs) because of the new functionalities and unique physiochemical properties anticipated from polymeric materials at the nanoscale. The development of HPNSs is reflected by the rapid increase in the number of scientific publications and patents on this subject in recent years. HPNSs in the size range of 1-1,000 nm with spherical or cylindrical geometries are of special interest. Spherical HPNSs generally include hollow polymeric nanospheres (HPNSPs), vesicles, or nanopoly-mersomes. Cylindrical HPNSs are basically polymeric nanotubes (PNTs). In view of possible biomedical applications, HPNSPs are potentially useful as encapsulates... 

Fig. 11 Preparation of hollow polymeric nanospheres via water-oil-water emulsion polymtaization...

Table 2.2 Summary of different polymeric nanosphere fabrication methods. 

Szczubialka, K., Jankowska, M., Nowakowska, M. Smart polymeric nanospheres as new materials for possible biomedical applications. J. Mater. Sd. Mater. Med. 14, 699-703 (2003)... 

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