Polymeric membranes integration

Challenges remain in the development of lab-on-a-chip sensing systems. The overall lifetime of a sensor chip is always determined by the sensor with the shortest lifetime, which in most cases is the depletion of reference electrolytes. Measures to minimize cross-talking among sensors, especially when biosensors are integrated in the system, also should be implemented [122], The development of compatible deposition methods of various polymeric membranes on the same chip is another key step in the realization of multisensing devices. 

In the following, a number of integrated reaction-separation systems wiU be discussed, with emphasis on the application of polymeric membranes. As a result, the systems discussed will be Hmited to relatively low temperatures, typically below 120°C. In Section 13.2, appHcations of membranes in chemical synthesis will be described. Subsequently, in Section 13.3 various examples of membrane bioreactors will be discussed. 

Schlosser, 5. (2000) Pertraction through liquid and polymeric membranes, in Integration of Membrane Processes into Bioconversions (eds K. Bako, L. Gubicza and M. Mulder), Kluwer Academic, p. 73. 

In biological membranes, integral proteins are amphipatic molecules their hydro-phobic moiety is embedded in the lipid bilayer and their hydrophilic moiety protrudes from the surface of the membrane279. So, it was interesting to prepare polymeric models of such amphipatic proteins. For that purpose, two new classes of block copolymers have been synthetized in Orleans, namely copolymers with a polyvinyl block and a polypeptide block and copolymers with a saccharide and a peptide block. We shall give some information concerning the preparation of these copolymers and then describe their structure. 

By inserting Henry s law (Equation 4.6) into Pick s law (Equation 4.1), integrating across the membrane and remembering the definition of the permeability coefficient (Equation 4.5), Equation 4.2 was developed as the standard equation for transport through a dense polymeric membrane. 

Schlosser S, Pertraction through hquid and polymeric membranes. In Belafi-Bako K, Gubicza L, Mulder M, Eds., Integration 0/ Membrane Processes into Bioconversions. Proceedings of thel 6th European Membrane Society Annual Summer School. Veszprem, Hungary, Aug. 1999. Kluwer Academic/Plenum Pubhshers, New York, NY, 2000 73-100. 

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