Polymerase chain reaction amplification factor

With this chip, DNA can be concentrated by a factor of up to two orders of magnitude. Khandurina et al. also reported an integrated system for polymerase chain reaction (PCR)-based analysis on a microchip with this preconcentration technique. The chip layout was similar to that depicted in Figure 50.30, with an additional Peltier thermoelectric element integrated for the DNA amplification. With this chip, a 25-fold preconcentration of the DNA sample due to the semipermeable silicate membrane was observed. 

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