Polymer-supported reagents, functional groups distribution

Distribution of functional groups in polymer-supported reagents wd catalysts has been studied with a scanning electron microprobe. Chloromethylation of 2% cross-linked 300-600 nm polystyrene beads with chloromethyl methyl ether and stannic chloride to 0.67 mequiv Cl/g (2S) followed by phosphination with lithium diphenyl-... 

Resins. The solid-phase support (Resin, Fig. 1) is a well-solvated polymeric matrix in which the peptide chains are attached throughout a resin bead. The polymeric backbone is a flexible superstructure through which reagents and solvents can easily flow and once swollen has the physical properties of a gel (144,145). This is in contrast to the common perception that solid-phase chemistry only occurs on the surface of each poljnner bead. Because of the permeable nature of the polymers, reaction rates approach but are slightly slower than that found in solution. Commercially available poljnners have functional group loadings typically in the 0.2-1.0 mmol/g range. As an example of the distribution... 

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