Polymer scaffolding

Song, J., Malathong, V. and Bertozzi, C.R. (2005) Mineralization of synthetic polymer scaffolds a bottom-up approach for the development of artificial bone. Journal of the American Chemical Society, 127, 3366—3372. 

Fabrication approaches have been previously used in two-dimensional (2D) micropattemed model systems and have led to insights on the effect of cell-cell and cell-polymer scaffold interactions on hepatocyte and endothelial cell fate. Extending these studies, the application of 3D fabrication techniques may also prove useful for studying structure-function relationships in model tissues. 

Brown RQ, Mount A, Burg KJ (2005) Evaluation of polymer scaffolds to be used in a composite injectable system for intervertebral disc tissue engineering. J Biomed Mater Res A 74(l) 32-39... 

Levenberg S, Huang NF, Lavik E, Rogers AB, Itskovitz-Eldor J, Langer R (2003) Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci USA 100 12741-12746. 

Simon CG Jr, Stephens JS, Dorsey SM, Becker ML (2007) Fabrication of combinatorial polymer scaffold libraries. Rev Sci Instrum 78 0722071... 

Sandanaraj BS, Vutukuri DR, Simard JM, Klaikherd A, Hong R, Rotello VM, Thayumanavan S. Noncovalent modification of chymotrypsin surface using an amphiphilic polymer scaffold implications in modulating protein function. J Am Chem Soc 2005 127 10693-10698. 

In this section, we focus on the strategies of controlling nanoparticle assemblies through functionalized polymer scaffolds, starting from interparticle spacing in bulk aggregates to 3-D morphologically controlled hierarchical nanostrucmres. 

Porous, biodegradable polymer scaffolds seeded with cells have been used to determine the feasibility of regenerating a number of organs. The goals and specific problems associated with regenerating several different organs are outlined below. 

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