Combinatorial Polymers

Combinatorial chemistry was developed as a method to generate large numbers of compounds that could be screened for numerous applications, primarily as drug 

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Green JJ, Langer R, Anderson DG (2008) A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res 41 749-759... 

Meier MAR, Schubert US (2004) Combinatorial polymer research and high-throughput experimentation powerful tools for the discovery and evaluation of new materials. J Mater Chem 14 3289-3299... 

Meier MAR, Schubert US (2005) Integration of MALDl-TOEMS as high-throughput screening tool into the workflow of combinatorial polymer research. Rev Sci Instrum 76 062211... 

Simon CG Jr, Stephens JS, Dorsey SM, Becker ML (2007) Fabrication of combinatorial polymer scaffold libraries. Rev Sci Instrum 78 0722071... 

Combinatorial polymer synthesis in combination with HTS is suitable for the fast qualitative detection of new compounds showing specifications of light-emitting diodes as the fluorescence brightness and film-forming properties can be checked simultaneously. 

Eidelman, N and Simon, CG. 2004. Characterization of Combinatorial polymer blend compostion gradients by FTIR microspectroscopy, J. Res. Natl. Inst. Stand. Technol., 109(2), 219-231. 

Potyrailo, R. A., Sensors in combinatorial polymer research, Macromol. Rapid Comm. 2004, 25, 77-94... 

Dickinson, T. A. Walt, D. R. White, J. Kauer, J. S., Generating sensor diversity through combinatorial polymer synthesis, Anal. Chem. 1997, 69, 3413-3418... 

Ngounou, B., Guschin, D.A., Castillo, )., and Schuhmann, W. (2009) Combinatorial polymer synthesis as a tool in biosensor and biofuel cell development and optimization. ECS Transactions, 19 (5), 119-128. 

Supramolecular Polymer Chemistry and Dynamic Combinatorial Polymers... 

Polyolefins are a highly versatile polymer class used in a number of commercial applications. The discovery of more selective and efficient catalysts for polyolefin synthesis is a constant demand, and high-throughput experimentation has received considerable attention to meet this need. " Many of the techniques developed to identify these catalysts closely mirror the methods used in small-molecule dmg discovery and may not be generally applicable to the combinatorial polymer generation. 

Fundamental Property Measurement with Combinatorial Polymer Coating and Film Libraries. 

Brey, D. M., C. Chung, K. D. Hankenson, J. P. Garino, and J. A. Burdick 2010. Identification of osteocon-ductive and biodegradable polymers from a combinatorial polymer hbrary. Journal of Biomedical Materials Research Part A. 93A 807-16. 

Yang, Y, D. Bolikal et al. 2008. Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D. Advanced Materials 20(11) 2037. 

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