Polymer device degradation functional groups

The possibility to modulate the degradation rate of the polymer, to insert functional groups for coupling pharmacologically active molecules and to introduce pH- or temperature-responsive segments has enhanced the interest towards these materials and various drug delivery devices have been fabricated in different forms, such as scaffolds, fibres, foams, nanoparticles and membranes (Kucinska-Lipka et al., 2015 Sartori et al., 2014 Mattu et d., 2012). 

Given the complex biological and chemical interaction between the polymeric implants and the in vivo environment of the host, the physiochemical properties of the polymers must be carefully considered in the selection of polymeric biomaterials that are biochemically appropriate for specific applications in implantable prostheses. Overall, the ideal material should minimize its adverse effects on the host tissues and immune system while resisting hydrolytic and oxidative degradation to achieve successful device integration and the intended long-term functionality. In addition, the choice of materials depends not only on the functions of the prostheses but also on other factors such as the site of implantation, the age group of recipients, and the intended period of use. 

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