Polymer controlled degradation

B. Gilg, H. MuUer, and K. Schwarzenbach. Paper presented Advances in Stabili tion and Controlled Degradation of Polymers, New Paltz, N.Y., June... 

J. C. Dawson and H. V. Le. Controlled degradation of polymer based aqueous gels. Patent US 5447199,1995. 

Decker, C. Second International Conference on Advances in the Stabilization and Controlled Degradation of Polymers, Preprints, Luzern, Switzerland, June 1980. 

Note 2 A controlled-degradable polymer is a polymer designed to degrade into products at a predictable rate. Such products are usually of lower molecular weight than the original polymer. 

The degradation rate can be controlled using acidic and basic excipients acidic excipients increase the degradation rates and facilitate a zero-order release rate over a 2-week period (Sparer et al. 1984). Basic additives increase the degradation time of the polymers and create a polymer that degrades specifically at the surface (Heller 1985). By careful choice of the excipient added, the degradation rate can be closely controlled. No experiments have shown the use of these polymers with proteins or peptides. This is not, however, indicative of the fact that these polymers are not compatible with proteins or peptides, but they are probably not the most appropriate polymeric carrier for oral delivery of biomacromolecules. 

Duynstee EFJ (1994) Proceeding of 6th international conference on advances in stabilisation and controlled degradation of polymers, Lucern... 

VI. FACTORS CONTROLLING THE RATE OF POLYMER PHOTOCHEMICAL DEGRADATION IN THE SOLID STATE 273... 

Factors Controlling the Rate of Polymer Photochemical Degradation 273... 

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