Polyhydroxy plant alkaloids glycosidase inhibitors

Molyneux, R.J., James, L.F., Ralphs, M.H., Pfister, J.A., Panter, K.E. and Nash, R.J. (1994). Polyhydroxy alkaloid glycosidase inhibitors from poisonous plants of global distibution Analysis and identification, in Colegate, S.M. and Dorling, P.R., Eds., Plant-associated toxins agricultural, phytochemical and ecological aspects, CAB International, Wallingford, pp. 107-112. 

Polyhydroxy Plant Alkaloids as Glycosidase Inhibitors and Their Possible Ecological Role... 

Fellows, L. E., S. V. Evans, R. J. Nash, and E. A. Bell, Polyhydroxy plant alkaloids as glycosidase inhibitors and their possible ecological role, in Natural Resistance of Plants to Pests M. B. Green and P. A. Hedin, eds.), ACS Symposium Series, American Chemical Society, Washington, DC, 1986. 

Aspidiaceae (Fellows et al., 1986 Janzen et al., 1990). These compounds are similar in some regards to coniine (48), a nonhydroxylated piperidine alkaloid. In some legumes, polyhydroxy piperidine alkaloids make up as much as 2% of the dry weight of the plant. These compounds are similar structurally to sugars and are potent inhibitors of glycosidase activity. Specificity varies and some compounds of this series inhibit mannosidases, others fucosidases, and so forth. No glucosidase inhibitor has been reported to present (Fellows et al., 1986) (also see Chapter 15). 

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