Polybrominated biphenyl epidemiology

Blanck HM, Marcus M, Tolbert BE, Rubin C, Henderson AK, Hertzberg VS, Zhang RH, Cameron L (2000) Age at menarche and Tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl. Epidemiology, 11 641-647. 

Henderson, A.K., Rosen, D.,MiUer,G.L.,etal., 1995. Breast cancer among women exposed to polybrominated biphenyls. Epidemiology 6,544—546. 

The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of polybrominated biphenyls (PBBs) and polybrominated diphenyl ethers (PBDEs). It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. 

Polybrominated Biphenyls. Symptoms of musculoskeletal effects, described as "joint pain" and "swelling in joints," were frequently cited health complaints in two epidemiological studies of groups of Michigan residents who were likely to have ingested PBB-contaminated food (Anderson et al. 1978c Landrigan et al. 

Polybrominated Biphenyls. No epidemiological studies were located that provided evidence for an association between exposure to PBBs and the occurrence of cancer in humans, although one case report is available concerning gastrointestinal cancer in a Michigan dairy farmer with known exposure to PBBs and other chemicals. 

Hoque A, Sigurdson AJ, Burau KD, ct al. 1998. Cancer among a Michigan cohort exposed to polybrominated biphenyls in 1973. Epidemiology 9(4) 373-378. 

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