Polyanions biological activity

Hydrophobization of Polyanionic Polymers to Achieve Higher Biological Activity... 

Since the pioneer work by Merigan in 1967 [1], many kinds of synthetic or natural polyanionic polymers have been examined for their biological activities [2-8], such as cytotoxicity, antiviral activity, antitumor activity, and immunomodulating activity. Although the biological results were interesting, the extent of activity for clinical application was still low. 

Several mechanisms between drug-encapsulated liposomes and cells was presented [9,10]. Sunamoto and coworkers [11] applied the liposomal technique for improving the biological activity of polyanionic polymers. 

We modified polyanionic polymers by use of a grafting reaction of hydrophobic groups onto the polymers. After an extensive evaluation for the affinity of the hy-drophobically modified (hydrophobized) polymers to cell membrane, the immuno-stimulating activity of polymers was investigated by in vitro or ex vivo experiments. Consequently, the increased biological activity was found in the hydrophobized polymer, indicating that... 

Polymeric drugs are macromolecules that elicit biological activity (7). Many synthetic polymers are biologically inert. However, some exhibit toxicity, while others exhibit a wide range of therapeutic activities. There are three kinds of polymer drugs polycations, polyanions, and polynucleotides. 

Belford, D.A., Hendry, LA. and Parish, C.R. (1993) Investigation of the ability of several naturally occurring and synthetic polyanions to bind to and potentiate the biological activity of acidic fibroblast growth factor. J. Cell Physiol. 157 184-189. 

THE ROLE OF MOLECULAR WEIGHT IN PHARMACOLOGIC AND BIOLOGIC ACTIVITY OF SYNTHETIC POLYANIONS... 

Regelson, W., Morahan, P., Kaplan, A. The role of molecular weight in pharmacologic and biologic activity of synthetic polyanions, in ref 228, p. 131... 

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