Polyanhydrides injectable systems

Polyanhydrides have been developed into various systems with mainly bone tissue engineering applications in mind. These polymers have mechanical strength much lower than that of bone but have been combined with other polymers, such as poly(imide)s, to resolve this problem. Polyanhydrides have been developed into photo-cross-linkable systems, based on dimethacrylated anhydrides, and also injectable systems, but little interest into these polymers with regard to tissue engineering has been taken in the recent past [82]. 

M.J. Kipper, E. Shen, A. Determan, and B. Narasimhan, Design of an injectable system based on bioerodible polyanhydride microspheres for sustained drug delivery. Biomaterials, 23, 4405-4412, 2002. 

Particulate systems (e.g., collagen, lactic or glycolic acids, polyanhydride or polyethylene vinyl coacetate) have several potential advantages for the therapeutic delivery of DNA (or of drugs), such as DNA encapsulation within the polymer can protect DNA degradation until release injection or implantation of the polymer into the... 

Several other biodegradable, biocompatible, injectable polymers are being investigated for drug delivery systems. They include polyvinyl alcohol, block copolymer of PLA-PEG, polycyanoacrylate, polyanhydrides, cellulose, alginate, collagen, gelatin, albumin, starches, dextrans, hyaluronic acid and its derivatives, and hydroxyapatite. ... 

---