Polyamines therapeutic properties

Likewise, due to their cationic properties polyamine moieties were found to enhance water solubiUty and cellular uptake of many therapeutic molecules, making them potential drug delivery agents. For most of the properties of polyamines the biological mechanisms are not well understood or are still in debate. Therefore, current research on natiu al and synthetic polyamines requires the synthesis of those compounds and many derivatives to investigate their function and to gain novel mimics for therapeutic applications. 

Up to the year 2000 many reviews emerged that described the classes of naturally occurring polyamines and the research on their synthetic polyamine conjugates [1]. Recently, polyamine alkaloids, toxins, and polyamines in cancer therapy have been reviewed in detail [2,20-22]. In this review, we will group the polyamines considering their properties, and focus exclusively on the therapeutic appUcations of polyamine compounds that gained interest from 1996 until the present, as well as on the new advances in polyamine synthesis and modification using solid phase... 

To date, many properties of polyamines are known to be interesting for therapeutic apphcation. These applications can be classified into five groups DNA recognition and binding development of antibiotics, bactericides, and an-tiparasitics natural product synthesis of toxins cancer therapy and drug dehvery. 

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