Polyamine transport system

Guminski Y, Grousseaud M, Cugnasse S et al (2009) Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system. Bioorg Med Chem Lett 19 2474—2477... 

Specific uptake systems may account for selective localization in tissues, and this may be the explanation for toxic effects in those particular tissues. For example, the herbicide paraquat (Fig. 3.16) is taken up by the polyamine transport system into the lungs and thereby reaches a toxic concentration (see chap. 7 for a detailed description of this system). 

Recent Advances in Bacterial Polyamine Transport Systems... 

In this chapter, recent understanding in bacterial polyamine transport systems is outlined in addition to an overview of polyamine transporters in E. coli. 

Bacteria and animals use ornithine decarboxylase in polyamine biosynthesis. However, the transport system for polyamines in bacteria through transporters is different from that of animals through endocytosis (Uemura et al. 2010). Some bacteria and most animals use ornithine decarboxylase for polyamine biosynthesis. However, the polyamine transport systems in bacteria are different from those of animals, which employ endocytosis (Uemura et al. 2010). Therefore, in view of the potential adverse effects that could result from the inhibition of polyamine biosynthesis in human, using an inhibitor of polyamine transport as a drug for prevention and control of pathogenic bacteria is a more attractive chemotherapeutic target than polyamine biosynthesis. 

Kashiwagi K, Igarashi K (2011) Identification and assays of polyamine transport systems in Escherichia coli and Saccharvmyces cerevisiae. Methods Mol Biol 720 295-308. doi 10.1007/978-l-61779-034-8 18... 

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