Polyacrylamide-grafted guar gum

Sen, G., Mishra, S., Jha, U. and Pal, S. Microwave initiated synthesis of polyacrylamide grafted guar gum (GG-g-PAM)-Characterizations and application as matrix for controlled release of 5-amino salicylic acid. Int J. Biol. Macromol, 47,164-70 (2010). 

Soppimath, K. S. and Aminabhavi, T M.. Water transport and drug release study from cross-hnked polyacrylamide grafted guar gum hydrogel microspheres for the controlled release apphcation. Eur. J. Pharm. Biopharm., 53,87-98 (2002). 

Fig. 6. The variation of drag reduction percentage with concentration in commercial, purified, and polyacrylamide grafted guar gum (GM3) ati e-14000 A Water x diameter = 1 mm, u = 0.57 O diameter = 3 mm, u = 0.06 (116,118).

Crosslinked microspheres of polyacrylamide grafted guar gum (pAAm-g-GG) by water-in-oil (w/o) emulsification method were developed. A 5.0% (w/v) polymer solution was prepared and acidified with 5 ml dilute sulfuric acid. In order to crosslink the polymer, glutaraldehyde solution 25% (w/v) was added to the polymer solution separately. These solutions were then emulsified into light liquid paraffin with 2% (w/v) Tween 80. The hardened microspheres were filtered and washed repeatedly with hexane and water to remove liquid paraffin, xmreacted glutaraldehyde and any adhered Tween 80. The crosslinked pAAm-g-GG microspheres were loaded with NFD before... 

Polyacrylamide grafted guar gum (GG-g-PAM) 5-amino salicylic acid Matrix tablets It was found that with higher % grafting, drug release rate declined. The release rate was found to be lower in acidic environment and higher in neutral and alkaline environment. [142]... 

Grafting of polyacrylamide onto guar gum [431] and Ipomoea gum [178] in aqueous medium initiated by the potassium persulphate/ascorbic acid redox system was performed in the presence of atmospheric oxygen and Ag" " ions. After grafting, a tremendous increase of the viscosity of both gum solutions was achieved, and the grafted gums were found to be thermally more stable. 

Table 5.2 Elemental analysis of guar gum and various grades of polyacrylamide grafted guar (GG-g-PAM)(reprinted from [49]).

Deshmukh SR, Chaturvedi PN, Singh RP (1985) The turbulent drag reduction by graft copolymers of guar gum and polyacrylamide J Appl Polym Sci 30 4013... 

Details are given of the ongoing research in the development of novel crosslinked hydrogel microspheres. Natural guar gum was grafted with polyacrylamide to give a copolymer matrix. Water uptake into these microspheres was studied to understand its effect on drug release. Verapamil hydrochloride was chosen as a model candidate. 10 refs. 

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