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Poly synthetic hydrogels preparation

Physically crosslinked PNIPAM-based hydrogels were described for the first time by Han et al [51], who synthesized poly(N-isopropylacrylamide-co-acrylic acid) (p(NIPAM-co-AA)) to prepare thermosensitive matrices that were used in follow-up studies for biomedical purposes, particularly as synthetic matrices in refillable bio-artifidal pancreas. Encapsulated Langeran islets showed good viability, and the cellladen artificial matrices showed insulin release [52,53]. Similarly and more recently, p(NIPAM) networks were crosslinked using N, N -methylenebisacrylamide (BIS) and used for bovine serum albumin (BSA) release studies in vitro. The release of the protein... [Pg.101]

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See also in sourсe #XX -- [ Pg.190 ]



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