Poly substrate recognition

Our present aim is to summarize the results obtained in the design of coreceptors capable of performing molecular recognition. Complexation of two or more metal ions by various macropolycyclic ligands to form di- or polynuclear cryptates will not be considered here (see ref. [15]). The discussion will be limited to substrate recognition by ditopic coreceptors for polyatomic molecular cations and anions and to developments towards poly topic coreceptors. 

Byme et al. [124] have shown the possibility of creating imprinted polymer ordered micropattems, of a variety of shapes and dimensions, on polymer and silicon substrates using iniferters and photopolymerization. They applied this approach to the recognition of D-glucose using copolymer networks containing poly(ethylene glycol) and functional monomers such as acrylic acid, 2-hydro-xyethyl methacrylate, and acrylamide. 

Nickel, A.M.L. Seker, F. Ziemer, B.P. Ellis, A.B. Imprinted poly (acrylic acid) films on cadmium selenide. A composite sensor structure that couples selective amine binding with semiconductor substrate photoluminescence. Chem. Mater. 2001, 13, 1391-1397. Sallacan, N. Zayats, M. Bourenko, T. Kharitonov, A.B. Willner, I. Imprinting of nucleotide and monosaccharide recognition sites in acrylamidephenylboronic acid-acrylamide copolymer membranes associated with electronic transducers. Anal. Chem. 2002, 74, 702 712. 

CD-grafted polymers synthesized from poly(iV-acryloxysuccinimide) (poly-NAS), mono-amino randomly methylated p-CD (RAME-p-CD— NH2), and pendant water-soluble phosphane moieties were also used as additives in the aqueous Rh-catalyzed hydroformylation of 1-hexadecene [25]. Within these polymers, both the supramolecular properties of the CD and the coordination ability of the phosphane were combined into the same molecular object. The catalytic results show that increasing the local concentration of the metal-phosphane complex and the CDs at the water/organic interface improves the reaction conversion. The explanation is that—after recognition of the substrate by the CDs, and as they are both graft on the polymer (CD and phosphane)—they... 

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