Poly -pyrene sensitivity

Many PSPs are composed of probe dyes, such as polycyclic aromatic hydrocarbons (e.g., pyrene) and coordination compounds (e.g., platinum por-phryins and ruthenium(II) polypyridyl complexes) immobilized in various gas permeable polymer films such as silicon polymer, organic glassy polymers (e.g., poly(methylmethacrylate), polystyrene), fluorinated polymers, or cellulose derivatives such as ethyl cellulose [9,10]. As probe molecules interact with polymer matrices directly, the properties of PSPs strongly depend on the properties of polymer matrices. The oxygen permeability of polymer matrix is an especially important factor for highly sensitive PSP. 

The approach of enzymatically sensitive polymers is also widely used in the case of polymeric micelles that physically encapsulate their cargo and release it upon enzymatic degradation of the polymer of which they are composed. One example of this is the work of Mao and co-workers (Mao and Gan, 2009). They synthesized amphiphilic diblock copolymers based on poly(glyddol-WocA - -caprolactone) (PG-h-PCL) with well-controlled structure and pendant hydroxyl groups along the hydrophilic block. These copolymers formed 74-95 nm micelles that demonstrated enzymatically triggered release of the encapsulated dye (pyrene) in the presence of lipase, due to degradation of the PCL block, which resulted in micelle dissociation. 

Oyama and Hirokawa [804] described a potentiometric pH sensor that used a film of poly(l-amino pyrene) (P(lAPyre)) in which no internal standard solution, as is required in conventional glass pH electrodes, was used. The pH detection was based on the sensor functioning as an ion-sensitive field effect transistor (ISFET). The sensor had high ion selectivity with respect to Na, and Ca, and insensitivity to O2, much like a conventional pH glass-membrane electrode. Response time was in the 30 to 60 sec region, with excellent linearity of response in the pH 4.0 to 10.0 region. 

Lin MH, Liu YJ, Yang ZH, Huang YB, Sun ZH, He Y, Ni CL (2012) Construction of sensitive amperometric immunosensor based on poly(amidoamine) dendrimer and one-step iraiic-liquid-assisted graphene/chitosan platform for benzo[a pyrene detection. Int J Electrochem... 

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