Poly polyglycolic acid

Poly(glycidyl methacrylate), 23 728 Polyglycolic acid, bioresorbable polymer, 3 736-737... 

From the viewpoint of polylactic acid and polyglycolic acid, byproducts of which are chemicals naturally present in body, the development of poly(amino acids) is genuine. However, the antigenic nature of the poly(amino acids) that contain three or more amino acids inhibits their widespread use. Besides, the cleavage of the amide bond depends on enzymes, resulting in poor in vivo controlled release. Poly(amino acids) have been used mainly to deliver drugs from implants in animals. 

Gilding, D.K. Reed, A.M. Biodegradable polymers for use in surgery—polyglycolic/poly(lactic acid) homo- and copolymers 1. Polymer 1979, 20, 1459-1464. 

Note DL-PLG Dl-poly(lacfic-co-glycolic acid) DL-PIA DL-polylactic acid L-PLA L-polylactic acid PGA polyglycolic acid PCL poly-e-caprolacfone. 

Synthetic or man-made, e.g., PVAl, CA, polylactams e.g., polycaprolactam), polyglycols (e.g., polyethylene glycol), poly(aspartic acid), poly(butylene succinate-co-adipate), as well as poly(3-hydroxy butyrate) or PHB, poly(P-hydroxybutyric acid) or PHBA, poly(hydroxy-valerate) or PHV, poly(lactic acid) or PLA, polyCglycolic acid), polyglycolides, polybu-tyric acid, their copolymers and mixtures. 

The most commonly used polymers in drug formulations include polyesters (such as poly(lactic-co-glycolic acid) (PLGA), polylactic acid, polyglycolic acid, and poly(c-caprolactone)), polyanhydrides (such as poly(sebacic... 

Similarly, the biodegradable polyesters polyglycolic acid and poly(f-caprolactone), also used for implantable devices (degradation even slower than that of PLA), drug delivery, and suture materials, are prepared by CROP using stannous octanoate and other catalysts as cationic initiators [8]. 

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