Poly nanofiber encapsulated

Su Y et al (2009) Poly(L-lactide-co-epsilon-caprolactone) electrospun nanofibers for encapsulating and sustained releasing proteins. Polymer 5O(I7) 4212-4219... 

Qi, R. Guo, R. Shen, M. Cao, X. Zhang, L. Xu, J. Electrospun poly (lactic-co-glycolic acid)/halloysite nanotube composite nanofibers for drug encapsulation and sustained release. J. Mater. Chem. 2010, 20 (47), 10622-10629. 

Electrospinning is an efficient technique for the fabrication of polymer fibers. Various cationic polymers have been successfully electrospun into ultrafine fibers, mostly from solvent solutions but some in melt form. Composite nanofibers of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning (Figure 16.5). ... 

Two types of poly electrolyte nanofiber mats were prepared in this study. One was polyacrylic acid (Mv = 450,000) fibers, spun from 5 wt% of aqueous solution. The other one was polysulfone fibers, spun from 25 wt% of DMF solution. The polysulfone fiber was then coated with a layer of polyelectrolyte, FAMPS, by a surface grafting technique (FAMFS-g-FS) similar to the procedure described previously. Nucrel membranes wereprepared by heat pressing Nucrel 535 (DuPont) pellets at 125°C. For fiber encapsulation, the fiber mats with measured weight and thickness were placed between two preweighed Nucrel membranes and then pressed at 125°C. The resulting composite membranes were flexible and robust with a homogeneous transparency. 

Zhang YZ, Wang X, Feng Y, Lim CT and Ramakrishna S, Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovin derum albumine)-encapsulated poly (s-caprolactone) nanofibers for sustained release . Biomacromolecules, 2006,7,1049-1057. 

Wang S, Zheng F, Huang Y, Fang Y, Shen M, Zhu M, Shi X (2012) Encapsulation of amoxicillin within laponite-doped poly(lactic-co-glycolic acid) nanofibers preparation, characterization, and antibacterial activity. ACS Appl Mater Interfaces 4 6393-6401... 

Zhang, Y. Z., X. Wang, Y. Feng, J. Li, C. T. Lim, and S. Ramakrishna (2006c). Coaxial electrospinning of (fluorescein isothiocyanatc-conjugated bovine serum albumin)-encapsulated poly(8-caprolactone) nanofibers for sustained release. Biomacromolecules 7(4) 1049-1057. 

Several anti-cancer drugs can be incorporated in polymer nanofibers for subsequent sustained release into the surrounding microenvironment. To date, paclitaxel is the agent most widely investigated in this framework. " Doxorubicin has also been studied as a model for encapsulation within biodegradable nanofibers of poly(ethylene glycol)-PLA copolymers. " ... 

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