Poly acid PLGA nanoparticles

Biodegradable polymer nanoparticles are PEG-coated poly(lactic acid) (PLA) nanoparticles, chitosan (CS)-coated poly(lactic acid-glycolic acid) (PLGA) nanoparticles, and chitosan (CS) nanoparticles. These nanoparticles can carry and... 

FOSS core conjugated-polymer (CP) shell structures, which were already described in the OLED section due to their high photoluminescent quantum yield, were also used in biomarker applications [100]. For this application they were loaded into poly(lactic-co-glycolic-acid) (PLGA) nanoparticles. The resulting particles showed high photoluminescent quantum yield, excellent stability, low cytotoxicity, and tunable surface protein density. The thus obtained nanoparticles were used in HER2-positive cancer cell detection. 

Electrospinning is an efficient technique for the fabrication of polymer fibers. Various cationic polymers have been successfully electrospun into ultrafine fibers, mostly from solvent solutions but some in melt form. Composite nanofibers of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning (Figure 16.5). ... 

This is a simple two-step process for the fabrication of nanoparticles. The first step is polymeric emulsification in an aqueous medium. The second step is solvent evaporation from the polymer and nanoparticle precipitation. Finally, the nanoparticles are collected by ultracentrifugation and washed with distilled water for the removal of excess stabilizer and lyophUization [23]. The various types of polymer used include poly(lactic-co-glycolic acid) (PLGA), poly-D,L-lactic acid (PLA), poly(E-caprolactone) (PCL), ethyl cellulose, poly(P-hydroxybutyrate), cellulose acetate phthalate, etc. 

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