Plocamium costatum

Tribromo-3,4,7-trichloro-3,7-dimethyl-1,5-octadiene (133) from the Australian alga Plocamium costatum deters the settlement of Balanus amphitrite larvae at 10 pg/ml [106]. 

Konig GM, Wright AD, de Nys R (1999) Halogenated Monoterpenes from Plocamium costatum and Their Biological Activity. J Nat Prod 62 383... 

I. J. Miller, Further evaluation of the structure of the polysaccharide from Plocamium costatum with the use of set theory, Hydrobiologia, 398/399 (1999) 385-389. 

One of the metabolites isolated from the red alga Plocamium costatum is a halogenated cyclized norgeraniolene, costatolide (170), ° and this has been synthesized. It has also been converted to the Cxo-compound costatone (171), isolated from the same alga, ° and placed here instead of in the pyran section because of the relationship with costatolide. In a synthesis of the latter, the (Z)-orientation of the vinyl chloride group could not be assured by chlorination... 

Konig, G.M. et al. (1999) Halogenated monoterpenes from Plocamium costatum and their biological activity. J. Nat. Prod, (si, 383-385... 

Kazlauskas, R., Murphy, P.T., Quinn, R.J., and Wells, R.J. (1976a) Two polyhalogenated monoterpenes from the red alga Plocamium costatum. Tetrahedron Lett., 17,4451-4454. 

Williard, P.G. and Grab, L.A. (1984) Total synthesis of costatone a monoterpene from the red seaweed Plocamium costatum. Tetrahedron Lett., 25, 5009-5012. 

---