Platinum complexes carboxylates

Tin, nitratodiphenyltris(dimethy) sulfoxide)-structure, 1,77 Tin, nitratotris(triphenyltin)-structure, 1, 47 Tin,tetrakis(acetato)-stereochemistry, 1,94 Tin, tetrakis(diethyldithiocarbamato)-angular parameters, 1, 57 Tin, tetrakis(ethyldithiocarbamato)-angular parameters, 1, 57 Tin, tetranitrato-stereochemistry, 1, 94 Tin, tri-n-butylmethoxy-, 3, 208 Tin alkoxides physical properties, 2, 346 Tin bromide, 3, 194 Tin bromide hydrate, 3,195 Tin carboxylates, 3, 222 mixed valence, 3, 222 Tin chloride, 3, 194 hydroformylation platinum complexes, 6, 263 Tin chloride dihydrate, 3,195 Tin complexes, 3, 183-223 acetyl ace tone... 

The metal hydride mechanism was first described for the cobalt-carbonyl-catalyzed ester formation by analogy with hydroformylation.152 It was later adapted to carboxylation processes catalyzed by palladium136 153 154 and platinum complexes.137 As in the hydroformylation mechanism, the olefin inserts itself into the... 

Pinacolone, o-(diphenylphosphino)benzoyl-coordination chemistry, 401 Piperidine, IV-hydroxy-metal complexes, 797 pA a values azole ligands, 77 Plant roots amino acids, 962 carboxylic acids, 962 Plastocyanin copper binding site, 557 copper(II) complexes, 772 copper(II) site in, 770 Platinum, dichlorobis(benzonitrile)-IR spectrum, 264 Platinum, cis-dichlorodianunine-antitumor activity, 34, 979 Platinum, ethylenebis(triphenylphosphine)-reactions with 5,6-dimethyl-2,l,3-benzothiadiazole, 194 Platinum blue formation, 265 Platinum complexes acetylacetone reactions, 380 amides, 491 amidines... 

Such an example has been demonstrated by Johnson and Sames, who chose a platinum-mediated dehydrogenation as a key step in the synthesis of the antimitotic rhazinilam 33 (Scheme 6) [20], The key intermediate 27 was converted into the imine 28, which was allowed to react with Me Pt(//-SMe2)]2 to afford the platinum complex 29. Subsequent treatment with triflic acid resulted in elimination of methane and furnished the cationic complex 30. Upon thermolysis in trifluoroethanol, the complex lost a second methane molecule, which resulted in the activation of the ethyl group. A subsequent /1-hydride elimination gave the hydrido-Pt(n) complex 31. Treatment with aqueous KCN followed by hydrox-ylamine removed the platinum and yielded the liberated amine 32. Johnson and Sames added a homologization and a macrolactamization and completed the total synthesis of rhazinilam (33) by removal of the carboxyl group. 

Diene platinum complexes such as (COD)PtCl2, (NBD)PtCl2 (NBD = norbor-nadiene) and (DPD)PtCl2 (DPD = dicyclopentadiene) easily react with nucleophilic reagents such as carboxylates, alkoxylates, amines and hydroxides to afford the addition products in high yields [8,114- 117]. For example, reactions are shown in eqs. (21.41)-<21.43). 

Perez-Soler, R., Han, I., Al-Baker, S., Khokhar, A. R., 1994, Lipophihc platinum complexes entrapped in liposomes improved stability and preserved antitumor activity with complexes containing linear alkyl carboxylate leaving groups. Cancer Chemother. Pharmacol. 33 378-384. 

Other work involving complexation of ferrocenylphosphines include the preparation of silver complexes of diferrocenylphosphine a trinuclear dirhenium complex dppf as a spacer ligand between rhenium centres dppf in gold complexes palladium and platinum complexes from the carboxylation of [(dppf)MCl2], M = Pd, Pt complexes technetium and rhenium heterometallic complexes mixed silver/nickel complexes ... 

Oxidative addition reactions of mercury carboxylates [Hg(02CR)2] with cis-[Pt(C6H4CH2NMe2-o)a] afford novel stable aryl-platinum-mercury complexes (22) the corresponding rrans-platinum complex forms unstable Pt-H intermediates, which eliminate Hg to leave isomers of [Pt(CeH4CH2NMe2)2-... 

Binuclear platinum(III) methyls have been made, these complexes utilizing carboxylate bridges (Figure 3.97b)... 

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