Platform technology products

BioVentures products and services oriented to the genomics research consist of a technological product platform composed by ... 

Although proteins can be expressed in many heterologous production systems, including bacteria such as Proteus mirabilis [1], fungi such as Pichia pastoris [2, 3] and Aspergillus awamori [4] and insect cells [5, 6], the pharmaceutical industry has narrowed down process development to a small number of platform technologies ... 

He has been responsible for pharmaceutical product development from exploratory development, preclinical, preformulation, and drug delivery platform technologies, formulation, process, and scale-up manufacturing toward commercialization. 

In view of current state of the art, namely, silicon-based technology, molecular electronics definitely exceed the expectations of a single product line. Going back, for instance, to 1960 silicon-based electronics were nearly exclusively considered as a simple replacement for the vacuum tube. However, it would have been myopic to limit the potential of silicon in that field of research. In fact, silicon constituted a technological platform, which evolved into the development of various products, most of them unfathomable at the time. Similarly, molecular electronics may be considered as a platform technology, rather than a single product line, which may give rise to many industrial products which are currently unforeseeable. 

These issues are common to all low-dose chug products and independent of platform technologies used in manufacturing the products. Therefore, it is important to understand and evaluate the factors affecting these quality attributes during product development. 

Each manufacturing platform has unique characteristics and complexity in terms of unit operations. Table 2.6 presents a fairly comprehensive (but by no means exhaustive) list of unit operation, process parameters, and quality attributes. Since more than one platform technology can be used to manufacture a drug product, selection of the most appropriate manufacturing platform is affected by many factors, such as ... 

As discussed earlier, one of the most important quality attributes for low-dose dmg products is uniformity of dose unit. Usually, dose strength of a dmg product is important in selecting a manufacturing platform technology. A simple decision tree on platform selection according to dose strength is described in Fig. 2.3 and is discussed below. 

If dose strength is less than 0.5 mg, direct compression or roller compaction may present significant challenges in achieving acceptable product content uniformity. In this case, explore other platform technologies. 

In order to structure the technology platform, various product groups produced with the same enzyme class are continuously enlarged based on prior experience. In Fig. 2, a series of chiral products prepared with hydrolases are shown and they are usually obtained with very high enantiomeric purities. Lipases and esterases have been the main contributors to the breakthrough of enzymatic methods in or-... 

An approach adopted by many has been the development of platform technologies. The aims of such a platform include for example, the provision of technology required to generate cell lines with high cell-specific productivity, to ensure the selection of production cell lines that perform well in the desired production process, to develop cost-effective production media, and to provide high-yielding, efficient and cost-effective production and purification processes suitable for large-scale manufacture. 

In the early days of eleclrolhermal atomization, matrix interference problems wore severe. As platform technology, new high-quality graphite materials, last photometric instrumenlation, and Zeeman background correction have developed, matrix interference problems have decreased lo Ihe level encountered wilh flames, Several methods have been developed for correcting for spectral interferences caused by matrix products, "... 

Rochfort S. Metabolomics revisited a new omics platform technology for systems biology and implications for natural products research. J Nat Prod 2005 68 1 81 3-1820. 

---