Platform chemical organic acids

COMMERCIALLY IMPORTANT PLATFORM CHEMICALS ORGANIC ACIDS ... 

Many industrial organic acids can be produced by fermentation, such as acetic, citric, and lactic acids. Succinic acid is a dicarboxylic acid of potential industrial interest as a platform chemical (1-3). Separation and purification of succinic acid by adsorption was tested to replace current precipitation methods and their associated waste disposal problems. Succinic acid is a valuable intermediate value chemical with a moderate market. For succinic acid to have an economic and energy impact, it will need to become a commodity chemical intermediate with a much lower price. This target price hasbeen estimated to be between 0.22 and 0.30 / lb ( 0.48- 0.66/kg) and is potentially achievable with advanced technology (1). At this price, succinic acid can be catalytically upgraded into other higher valued chemicals suchastetrahydrofuran, 1,4-butanediol, y-butyrolactone, 2-pyrrolidinone, and N-methylpyrrolidinone. 

Becker, J., Lange, A., Fabarius, ]., and Wittmaim, C. (2015) Xop value platform chemicals bio-based production of organic acids. Curr. Opin. Biotechnol, 36, 168—175. 

Succinic acid can be produced by anaerobic fermentation of several wild-type strains Anaerobiospirillum, Propionibacterium, Escherichia,Pec-tinas. Succinie aeid is eonsidered as one of the major bio-based platform ehemieals (Figure 1.9). Its applieations are foreseen as well in commodity chemicals (THF, hydrojgrsuccinimide etc.), as organic acids (malic, fumaric, itaconic etc.) or polymers (polybutylene succinate, PBS). ... 

Biofuels, bulk biopolymers, commodity, and platform chemicals Amino and organic acids Industrial enzymes Vitamins... 

Thus the purpose of this chapter is to summarize the advances and future commercial importance of biomass-derived platform chemicals, including different organic acids and alcohols are presented across (Tables 1.1-1.4). 

Succinic acid and its salts, produced through the fermentation of glucose, form a platform from which many chemicals can be produced. Since most fermentation organisms are not tolerant of acidic conditions, the fer-... 

The study of heterocyclic compounds constitutes a major endeavor in the fields of organic chemistry and the life sciences. Although numerous texts on the synthesis, structure, and reactivity of heterocyclic compounds have been written [1,2], the application of solid-acid catalysts to the synthesis of heterocyclic compounds is rarely emphasized in the literature. The authors of this section of the book have chosen not to pursue an exhaustive literature review-type approach to this topic but rather to cover selected areas of this subject from the viewpoint of an industrial chemist. More specifically, an account of the synthesis of pyridines is given which relies heavily on patent literature. Pyridine bases constitute a sizable semicommodity industry that provides a platform into the pyridine derivatives that are precursors to numerous fine chemicals. In addition, this section includes selected examples of the synthesis of non-pyridine heterocycles which might be of commercial importance. 

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