Platelets procoagulant activity

Platelet activation leads to the formation of platelet-derived microparticles derived from the platelet surface. These microvesicles typically account for 25% to 30% of platelet procoagulant activity and factor V binding sites (34,39),... 

Pedicord DL, Greco NJ, Jamieson G A, Didcer IB GPIb mediates thrombin-induced platelet procoagulant activity. Thromb Haonost475,1997(abstr)... 

M2. Maier, R. V., Hahnel, G. B., and Fletcher, J. R Platelet-activating factor augments tumor necrosis factor and procoagulant activity. J. Surg. Res. 52,258-264 (1992). 

Wiedmer T, Esmon CT, Sims PJ, Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombi-nase, Blood 1986 68 875-880,... 

Schematic view of the role of coagulation factor Xa in arterial thrombosis. After endothelial injury, platelets adhere to the subendothelial matrix. The procoagulant activity of the arterial clot can be attributed to the formation of the prothrombinase complex on the platelet surface which cleaves prothrombin and produces thrombin. Thrombin subsequently acts as a strong agonist of further platelet aggregation.

Lorant DE, Zimmerman GA, McIntyre TM, Prescott SM. Platelet-adivating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. Sem Cdl Biol 1995 6 295-303... 

Tans G, Rosing J, THOMASSBI MC, Heeb MJ, Zwaal RF, Griffin JH. Comparison of antico ant and procoagulant activities of stimulated platelets and platdet-derived micropartides. Blood 77,2641-2648, 1991. 

Intact platelets do not show procoagulant phospholipids on their exterior. These phospholipids are located on the inside leaf of the bilayer membrane (H6). They become accessible when the platelets are disrupted or by a process initiated by small amounts of collagen and thrombin that shifts these procoagulant agents from the inside to the outside. Both in prothrombin and intrinsic Factor X activation, phospholipids cause a sharp decrease in the for prothrombin and Factor X, respectively (T2). The procoagulant activity of the platelets is usually called platelet factor 3 (PF3). In the circulating blood... 

Jesty J and Bluestein D (1999) Acetylated prothrombin as a substrate in the measurement of the procoagulant activity of platelets elimination of the feedback activation of platelets by thrombin. Anal Biochem 272 64-70 Ayers MR and Hunt AJ (2001) Synthesis and properties of chitosan-sihca hybrid aerogels. Journal of Non-Crystalline Solids 285 123-127... 

The preparation and the assay of the components of fibrinolysis and thrombolysis have been reviewed." The amino-acid sequences at the NH2-terminus, molecular weights, and amino-acid compositions of human prothrombin, factors IX and X, and a new plasma protein have been compared." Desialylation of human plasma factor VIII decreased its ristocetin-induced platelet-aggregation activity and facilitated its clearance by hepatocytes, but its procoagulant activity was not affected." " Experiments in vivo have confirmed the view that the inhibi-... 

Thiagarajan, P. and Tait J.F., 1990, Binding of annexin V/placental anticoagulant protein 1 to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J. Biol. Chem., 265 17420-17423. 

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