Platelet physiology

Detwiler and co-workers were the first to demonstrate a role for csPDI in platelet physiology (Chen et al, 1995 Essex et al, 1995). Essex and co-workers (1999, 2001) and Hogg and co-workers (Burgess et al., 2000) showed that the inactivation of csPDI with anti-PDI antibodies and thiol alkylating agents inhibited platelet activation and aggregation. Recent studies have identified two distinct activities for csPDI. 

The appropriateness of using platelets, as a cell mirroring some neurochemical processes, finds its rationale in the numerous similar features of platelets and neurones Platelets store and release neurotransmitters and express appropriate neurotransmitter transporters and some neurone-related proteins such as NMDA receptors. Along these lines, different authors reported abnormalities in platelets physiology and function in AD. At first, Zubenko and colleagues described an alteration in platelet membrane fluidity in AD patients [99]. Other studies, performed on platelets obtained from patients with moderate to severe AD, reported cytoskeletal abnormalities, cytochrome oxidase deficiency, abnormal cytoplasmic calcium... 

Jurk K, Kehrel, B. Reliability of platelet function tests and drug monitoring platelets physiology and biochemistry. Semin Thromb Hemost 2005 3 1 381-392. 

Platelet physiology and the rationale for glycoprotein Ilb/IIIa inhibitors... 

Michelson AD, Catteneo M, Eikelboom JW, et al. Aspirin resistance position paper of the working group on aspirin resistance, platelet physiology subcommittee of the scientific and standardization committee, International society on thrombosis and haemostasis. J Thromb Haemost 2005 3 1309-131 I. 

Caen JP, Cr< berg S, Kubisz P. Platelet physiology and pathology. New York Strabm Intercontinental Meddal Book Co, 1977. 

Reimers, HJ, adenine nucleotides in Mood platelets. In The platelets Physiology and pharmacology (ed Longenecker, GSX Academic Press, NY, 1985,85-112. 

This chapter will review and contrast platelet physiology of various animal qrecies. Additionally, where it contributes to understanding physiologic responses of platelets, platelet function defects will be discussed. Specific species discussed include horse, cow, sheep, goat, dog, cat, pig, rabbit, rat, mouse, Guinea pig, and bird. 

Handbook of platelet physiology and pharmacology / edited by Gundu H.R. Rao. p. cm. 

Weiss JM. Platelet physiology and abnormalities of platelet function (Part II). N Engl J Med 1975 293 531. 

The platelets are mainly composed of protein and lipids. Protein represents 60% of the dry weight of platelet. Many of the platelet proteins are enzymes (catalase, hyaluronidase, esterase, j8-glucuronidase, nucleotidase, tryptase, tyrosinase, and pyrophosphatase). Many of the enzyrries in platelets are hydrolases, which may well reflect platelets physiological role. 

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