Platelet aggregation inhibiting activity

Interestingly, only the enantiomencally pure (+)-clopidogrel (2) exhibits platelet aggregation inhibiting activity, while the (-)-(2) is inactive.16 Moreover, the inactive (-)-... 

Sotelo, E., Fraiz, N., Yanez, M., Terrades, V., Laguna, R., Cano, E. and Ravina, E. 2002. Pyridazines. Part XXIX Synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2//)-pyridazinones novel aspects of their biological action. Bioorg. Med. Chem. 10 2873—2882. 

New nitrosothiols are being synthesized and tested for activity. These include structures 1-6 in Section II.A as well as those derived from cysteine residues within proteins. One example of a S-nitrosocysteine within a polypeptide46 is remarkably stable in the solid form, contrasting with the marked instability of S-nitrosocy stein e itself. The S,S dinitrosodithiol 11 has been shown to have platelet aggregation inhibition properties of the same order of magnitude as GTN and vasodilation properties somewhat less than those possessed by GTN17. 

Platelet aggregation inhibition. Methanol extract of the fruit, at a concentration of 500 pg/mL, produced weak activity on human platelets vs collagen-induced... 

The 6- or 7-phenyl-substituted l-ethyl-pyrazino[2,3-r-][l,2,6]thiadiazine 2,2-dioxides 187 were found to show significant platelet aggregation inhibition comparable to other antithrombotic agents. Strong evidence was found that this activity was due to interference with the platelet arachidonic acid pathway <1999JME1698>. 

Broussoflavan A (36) Antioxidant activity (inhibition of lipid peroxidation) Platelet aggregation inhibitory activity 1 [43] [45]... 

In the course of another screening for the induction of GST activity in RL34 cells, MS-ITC was inadvertently isolated from wasabi as a potential inducer of GST. MS-ITC administered to rodents also showed both activities in vivo. As a result of elucidation of the platelet aggregation inhibition and the GST induction mechanisms of MS-ITC, the isothiocyanate moiety of MS-ITC plays an important role for antiplatelet and anticancer activities because of its high reactivity with sulfhydryl (RSH) groups in biomolecules (GSH, cysteine residue in a certain protein, etc.) (Figure 42.3). 

PGR analog/mimetic (epoprostenol, FR181157) Sildenafil Inhibits platelet aggregation Inhibits type-5 phosphodiesterase and reduces platelet activation... 

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