Platelet-activating factor inhibitors

Ketotifen Hrreceptor antagonist, mast cell stabilizer, eosinophil inhibitor, platelet-activating factor inhibitor May inhibit eosinophil chemotaxis... 

Thienotriazolodiazepines derivatives, (I), were initially prepared by Braquet (1) in a 11-step synthetic process and were effective as platelet-activating factor inhibitors and used as antiasthmatic, antiallergic, and gastrointestinal protects. 

Yang, H.O., and B.H. Han. 1998. Pinusolidic acid A platelet-activating factor inhibitor from Biota orientalis. Planta Med. 64[Pg.679]

Beck JC, Goodner CJ, Wilson C, Wilson D, Glidden D, Baskin DG, Lemmark A, Braquet P (1991) Effects of ginkgolide B, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic BB rat. Autoimmunity 9(3) 225-235... 

Platelet-activating Factor Platelet Aggregation Inhibitors Platelet-derived Growth Factor Receptor Platelet Inhibitors Platelets... 

K10. Klabunde, R. E., and Calvello, C., Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. Shock 4, 368-372 (1995). 

Ginkgo leaf extract appears to act primarily as a mild cerebral vasodilator that increases cerebral blood flow and reduces blood viscosity. Ginkgolides inhibit platelet activating factor, and this may improve microcircula-tory blood flow in atherosclerotic disease with slightly increased risk of bleeding. There appears to be an antioxidant effect that may be neuroprotective. Although some studies suggested a monoamine oxidase inhibitor (MAOI) effect, this is considered to have questionable clinical relevance. 

Pharmacologic inhibitors of thrombin. Thrombin is a key enzyme in the hemostatic system in that it leads to the formation of fibrin strands and is a potent stimulus for platelet activation. Thrombin inhibitors, factor Xa inhibitors, and antiplatelet drugs act at different points in the hemostatic system to regulate the amount of thrombin that is generated. 

Sugatani J, Miwa M, Hanahan DJ. Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (chymotryptic protease inhibitor). J Biol Chem 1987 262 5740-5747... 

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