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Fluorescence Imaging In vivo

Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, Webb WW (2003) Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 300 1434-1436... [Pg.90]

CNTs were functionalised with both PEG, to ensure colloidal stability, and the DNA oligonueleotide ds(AAAT)y to produce a seleetive NO fluorescence response upon exposure to NO, the nanotube fluoreseenee (Xexc = 785 nm, Xexc 1000nm) is quenehed by 75%. The effieaey of the NO nano-sensor was assessed using a mouse model with an intense inflammatory response, and following injeetion, the liver was exposed and image in vivo, and fluorescence quenehing was observed in inflamed organs, but not in control mice. [Pg.297]


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