Plasmon Ruler

Development of Nanocrystal Molecules for Plasmon Rulers and Single Molecule Biological Imaging... 

Fig. 9.2. Cartoon illustrating changes in the light scattering spectra when two noble metal nanoparticles are brought into close proximity to each other. The plasmon resonance splits into longitudinal and transverse modes, with scattering from the longitudinal mode more intense. This can be used as the basis for a plasmon ruler with application in single molecule biophysics...

Fig. 9.5. Calibration of the plasmon ruler by single molecule light scattering. The peak of the light scattering spectrum is observed for different lengths of DNA. Collaborative work with Prof. Jan Liphardt [17]...

The plasmon rulers shown here can be extended to work in vivo as well. We have recently developed nanocrystal molecules joined together by peptides, and we have shown that their light scattering can be detected when the particles are introduced into the cytoplasm of living cells. Further, we have shown that we can detect the cleavage of the peptides when specific byproteases are activated [20]. 

Absorption of and Emission fiom Nanoparticles, 541 What Is a Surface Plasmon 541 The Optical Extinction of Nanoparticles, 542 The Simple Drude Model Describes Metal Nanoparticles, 545 Semiconductor Nanoparticles (Quantum Dots), 549 Discrete Dipole Approximation (DDA), 550 Luminescence from Noble Metal Nanostructures, 550 Nonradiative Relaxation Dynamics of the Surface Plasmon Oscillation, 554 Nanoparticles Rule From Forster Energy Transfer to the Plasmon Ruler Equation, 558... 

Nanoparticles Rule From Forster Energy Transfer to the Plasmon Ruler Equation... 

Jain P, Huang W, El-Sayed M. 2007. On the universal scaling behavior of the distance decay of plasmon coupling in metal nanoparticle pairs A plasmon ruler equation. Nano Lett. 7 2080-2088. 

Sonnichsen C, Reinhard BM, Liphardt J, Alivisatos AP. A molecular ruler based on plasmon coupling of single gold and silver nanoparticles. Nat Biotechnol 2005 23 741-5. 

Lal, S., Grady, N.K., Goodrich, G.P., and Halas, N.J. (2006) Profiling the near field of a plasmonic nanoparticle with Raman-based molecular rulers. Nano Letters, 6, 2338-2343. 

Reinhard B, Siu M, Agarwal H, Alivisatos A, Liphardt J. 2005. Calibration of dynamic molecular rulers based on plasmon coupling between gold nanoparticles. Nano Lett. 5 2246-2252. 

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