Plasminogen, fragment

R18. Rouy, D., Koschinsky, M. L., Fleury, V., Chapman, J., and Anglds-Cano, E., Apolipopro-tein(a) and plasminogen interactions with fibrin A study with recombinant apolipoprotein(a) and isolated plasminogen fragments. Biochemistry 31, 6333-6339 (1992). 

Raskopf E, Gerceker S, Vogt A, Standop J, Sauerbruch T, Schmitz V. Plasminogen fragment Kl-3 inhibits expression of adhesion molecules and experimental HCC recurrence in the liver. I em ionglJ jj ij lo ColorectalDisea 2009 24 837-844. 

In a different approach, a TNF fusion protein designated TNF-Selectokine has been described [5]. This TNF prodrug is comprised of a trimeric scFv-TNF fusion protein to which a TNFR fragment has been fused at the C-terminal. A flexible peptide linker between TNF and the blocking receptor domain is comprised of sequences specifically recognized by tumor associated proteases such as tissue plasminogen activator, urokinase type plasminogen activator or... 

The lysine binding sites on free Lys-plasminogen or free Lys-plasmin are susceptible to inhibition by a2 plasmin, the primary inhibitor of plasmin, because these sites are not protected by interaction with fibrin. However, when Lys-plasminogen is tightly bound to the fragment E domain, it is rapidly activated by the... 

Interaction ofLp(a) in the Process of Activation of Plasminogen to Plasmin by Tissue-Type Plasminogen Activator on Fibrin, Fibrinogen, and Fibrin(ogen) Fragments... 

Brash has also used CD to study eluted proteins and finds large changes in a-helix content of fibrinogen, perhaps due to enzymatic fragmentation produced by the surface-induced activation of plasminogen to plasmin11 18). 

---