Plaque morphology

Nesto RW, Waxman S, Mittleman MA, et al. Angioscopy of culprit coronary lesions in unstable angina pectoris and correlation of clinical presentation with plaque morphology. Am J Cardiol 1998 81 225-228. 

Nakata Y, Maeda N. Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic Acid. Circulation 2002 105 1485-1490. 

Superior to DSA, MRI can depict arterial flow or lumen as well as the vessel walls. Analysis of plaque morphology was improved in recent years by the development of specific MRI techniques. Plaques can now be characterized in vivo with regard to fibroid or lipid content or hemorrhagic lesions (Fig. 5.8). It can be expected that, in the future, plaque examination will influence stroke treatment protocols if the risk of plaque rupture can be reliably estimated (Cappendijk et al. 2005 Hayes et al. 1996 Trivedi et al. 2004 Yuan et al. 2001). Plaque examinations, however, are not yet clinical routine. Source images of TOF-MRA allow only limited assessment of vascular walls. 

In AD neurons, there are three main types of neurofibrillary lesions (NFLs) according to their intracellular localization neurofibrillary tangles (NFTs) inside the cell body and apical dendrites, and neuropil threads (NThs) in distal dendrites and dysrophic neurites, associated with senile plaques. Morphologically, three major subtypes of NFTs can be distinguished, corresponding to different evolutionary stages of these lesions. 

Once constructed, the plasmid sequences are introduced into the virus chromosome by co-transfection of the plasmid with naked wild type viral DNA. Recombination occurs at a low but useful frequency between these DNAs at their homologous regions, flanking the polyhedrin gene. The progeny virus from the co-transfection are plaqued, and the plaques are scored for type. Under a dissecting microscope, the recombinants can be selected from the wild types based on their distinctive plaque morphology due to a lack of PIBs. Once selected and a stock prepared, one has a virus which on infection of cells will direct the production of both additional virus and the product of the... 

Hodgson, J., Reddy, K., Suneja, R., et al. (1993) Intracoronary ultrasound imaging correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty, J. Am. Coll. Cardiol., 21, 35 4. 

Bauters C, LablancheJM, Renaud N, McFadden EP Hamon M, Bertrand ME. Morphological changes after percutaneous transluminal coronary angioplasty of unstable plaques. Insights from serial angioscopic follow-up. Eur Heart J 1996 ... 

Harrington R. (1985) A comparison of the external morphology of scent plaques on the hind tibiae of oviparous aphids (Homoptera Aphididae). Systematic Entomol. 10, 135-144. 

Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation 110 2190-2197... 

Rothwell PM, Gibson RJ, Villagra RC et al. (1998). The effect of angiographic technique and image quality on the reproducibility of measurement of carotid stenosis and assessment of plaque surface morphology. Clinical Radiology 53 439-443... 

Rothwell PM, Gibson R, Warlow CP on behalf of the European Carotid Surgery Trialists Collaborative Group (2000b). Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. Stroke 31 615-621... 

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