Plahnum complexes

Whereas, plahnum complexes are used predominantly as efficient catalysts in the hydrosilylation of carbon-carbon mulhple bonds, cobalt and iron triad complexes play a cmcial role in the catalysis of other processes, such as the hydrosi-lylahon of C=0 and C=N, dehydrogenative silylation, sUylcarbonylahon, and silylation with vinylsilanes and disilanes. 

Cancerous cells multiply very rapidly because ceU division is uncontroUed. Thus these and similar plahnum complexes were evaluated as antitumor agents, which inhibit the division of cancer ceUs. The results showed that... 

PtMe2(OR)(N-N)(OH2)] OH (47) (Eq. 6.16) [30, 31]. These complexes, likely resulting from an oxidative ROH addition, were characterized by elemental analysis, IR and NMR spectroscopy, conductivity measurements and conversion to derivatives containing weakly coordinating bulky anions. These reachons are of interest because they represent the first examples of oxidation of plahnum(ll) complexes with alcohols and provide the first stable alkoxoplahnum(lV) complexes. The alkoxo-platinum(lV) bond is inert against solvolysis by alcohols, water and even dilute perchloric acid. 

Platinnm(TV) has a coordination number of 6. It forms complexes with halides, nitrogen and sulfur compounds, and other donors but to a lesser extent than plahnum(ll). 

Although there has been a great deal of research concerning how plahnum(II) complexes bind to biological molecules and the hkely mechanism of antitumor activity of these platinum-containing species, far less attention has been paid to the properties of other metal complexes in this arena. Recent attention has fallen on cobalt(II)-Schiff base complexes, as several have been discovered to have promise as antiviral agents. A review of recent work has appeared elsewhere [64], so the topic will not be covered here however, in addition to focusing on recent developments, emphasis is placed on the introduction of the new head unit, 3,6-diformylpyridazine (13), into Schiff-base macrocyclic electrochemistry. 

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