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PKC inhibition

Stimulation of PKA and PKC inhibit NHE5 activity, as does hyperosmolarity, resembling the responsiveness of NHE3. NHE5 may also be regulated by the actin cytoskeleton, but further work is required to validate this notion and clarify the exact mechanism. [Pg.811]

Studies of PKC and anxiety provide a particularly good example. The knockout of either the or y isoform confers resistance to anxiety and potentiates the action of benzodiazepines. Furthermore, PKC inhibition may have... [Pg.904]

Vitamin E (tocopherol), which is a major lipid-soluble antioxidant, inhibits the differentiation of smooth muscle presumably by modulating the activity of protein kinase C. PKC inhibition by tocopherol has also been implied in human platelets. [Pg.202]

PKC inhibition p42/p44 MARK inhibition c-Src inhibition increased cAMP... [Pg.250]

Clarke M, Dodson PM. (2007) PKC inhibition and diabetic microvascular complications. Best Pract Res Clin Endocrinol Metab 21 573-586. [Pg.187]

Meyer T, Regenass U, Fabbro D, Alter E, Rdsel J, Muller M, Carvatti G, Matter A (1989) A derivative of staurosporine (CGP 41251) shows selectivity for PKC inhibition and in vitro antiprolif erative as well as in vivo antitumor activity. Int J Cancer,43 851-856... [Pg.82]

Sommers GM, Alfieri AA (1998) Multimodality therapy radiation and continuous concomitant ds-platinum and PKC inhibition in a cervical cardnoma model. Cancer Invest 16 462-470... [Pg.90]

Since phenolic compounds are ubiquitous in many plants, another, more-specific method for examination of the extract was sought. The ideal method would allow homologs of 1 to 3 to be targeted specifically. (By this point of the work, the PKC inhibition bioassay was no longer available to us as a screening tool. In any event, this bioassay would not readily pick up homologs of 1 to 3 which were inactive, yet which are important for structure-activity relationship studies.) The most practical method proved to be the use of MS and MS-HPLC techniques to identify potential homologs in the extract. [Pg.173]

Compound DPPS °c DPPS 7"max slope DPPC 7"max slope BBPS i/r2 slope MCF-7/DOX P388/DOX PKC inhibition ic50 ( M)... [Pg.263]

See other pages where PKC inhibition is mentioned: [Pg.18]    [Pg.1295]    [Pg.176]    [Pg.756]    [Pg.386]    [Pg.65]    [Pg.75]    [Pg.19]    [Pg.20]    [Pg.22]    [Pg.27]    [Pg.29]    [Pg.37]    [Pg.40]    [Pg.42]    [Pg.43]    [Pg.54]    [Pg.60]    [Pg.117]    [Pg.100]    [Pg.757]    [Pg.231]    [Pg.175]    [Pg.177]    [Pg.538]    [Pg.588]    [Pg.348]    [Pg.248]    [Pg.283]    [Pg.77]    [Pg.308]    [Pg.1295]   
See also in sourсe #XX -- [ Pg.80 ]

See also in sourсe #XX -- [ Pg.80 ]



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