Pirbuterol

2-Pyrrolidone is first reacted with sodium hydride, then with ethyl chloroacetate to give ethyl 2-OXO-1 -pyrrolidine acetate. 

A solution of 0.3 mol of ethyl 2-oxo-1-pyrrolidine acetate in 300 ml of methanol, saturated with ammonia at 20° to 30°C, is heated at 40° to 50°C for 5 hours, while continuously introducing ammonia. The reaction mixture is evaporated to dryness and the residue recrystallized from isopropanol. 2-Oxo-1-pyrrolidineacetamide is obtained in a yield of 86%. 

Morren, H. U.S. Patent 3,459,738 August 5,1969 assigned to UCB (Union Chimique-Chemi-sche Bedrijven), Belgium 

Chemical Name 2-Hydroxymethyl-3-hydroxy-(1-hydroxy-2-tert-butylaminoethyl)pyridine Common Name — 

N-tert-butyl-2-(5-benzyloxy-6-hydroxymethyl-2-pyridyl )-2-hydroxyacet amide 

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N-tert-Butyl-2-(5-benzyloxy-6-hydroxy-methyl-2-pyr idyl)-2-hydroxy acetamide Pirbuterol Butyl bromide Bufexamac Bupivacaine Fenipentol sec-Butyl bromide... 

FIGURE 9.15 In vivo effec ts o f P-adreno cep tor partial agonis ts o f differing in trinsic efficacy. Changes in heart rate (increases in beats/min) shown in anesthetized cats. Chloralose/pento barbital anesthesia (filled circles) yield low basal heart rates, while urethane/pen to barbital anaesthesia (open circles) yields high basal heart rates. Responses to (in order of descending relative intrinsic efficacy) (a) pirbuterol, (b) prenalterol, and (c) pindolol. Redrawn from [50],... 

C7H7Br 100-39-0) see Fosinopril Latanoprost Monobenzone Orlistat Pirbuterol Saquinavir benzyl bromoacetate... 

C 2H N203 15235-97-9) see Clenbuterol a -IKld-dimethylethyllaminolmethylj-S-Iphenyl-methoxy)-2,6-pyridinedimethanoI (C, H2f.N20, 38029-09-3) see Pirbuterol... 

C5H5NO 109-00-2) see Distigmine bromide Pirbuterol Pyridostigmine bromide... 

CH3NO2 75-52-5) see Baclofen Gabapentin Midazolam Pirbuterol Ranitidine Ropinirole Trometaniol l-(2-nitro-4-methoxyphenyl)-2-nitropropcnc C oHi()N203 25803-11-6) see Clometacin 4-(5-nitro-l-methylindol-3-ylmethyl)-3-methoxybenzoic acid... 

Pirbuterol Inhalation 5 minutes 0.5-1.5 hours 4-5 hours MDI (200 mcg/puff) 1-2 puffs every... 

Levalbuterol nebulizer solution Levalbuterol MDI (45 mcg/puff) Pirbuterol MDI (200 mcg/puff) Systemic /J-agonists... 

Phenytoin 56 Phoslo 14, 20 Phosphate 56 Phytonadione 56 Pindolol 56 Pioglitazone 56 Piperacillin 56, 84 Piperonyl Butoxide 81 PipradI 56 Pirbuterol 56 Piroxicam 56 Pitressin 68... 

Pirbuterol, 280 Piromidic acid, 470 Pirprofen, 69 Pizotifline, 420 Poldine, 74... 

One of the first 8-adrenoreceptor agonists used both currently and in the past as a bron-cholytic is epinephrine or adrenaline, isoproterenol, and especially ephedrine. In treatment and prevention of obstructive respiratory tract diseases, other j3-adrenoreceptor agonists also are used, such as isoetharine, terbutaUne, albuterol, metaproterenol, and also those described in this section—fenoterol (23.3.16), pirbuterol (23.3.22), and procaterol (23.3.25). 

Like pirbuterol, procaterol exhibits similar broncholytic properties as albuteral, but it has somewhat of a more prolonged action. It is recommended for use as an inhaled drug for treating bronchial asthma. Synonyms of this drug are onsukil, masacin, procadil, meptin, and others. 

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