Piperidine, 4-amino-2,2,6,6-tetramethyl

Fig. 3 Detail of the O- - I interaction in the binary system associating the 4-amino-2,2,6,6-tetramethyl(piperidin-l-yloxyl) radical 7 with pTFDIB... 

For a,a-dialkylamino acids enantiomerization is not a problem. The preparation of 4,4-dimethyl-2-[(9-fluorenylmethyl)oxy]-5(4F/)-oxazolone, an intermediate used in the synthesis of ( )-mirabazole C has been described. Recently, two new 2-aIkoxy-5(4F/)-oxazolones derived from Toac (2,2,6,6-tetramethyl-4-amino-l-oxy-piperidine-4-carboxylic acid) that incorporate Z or 9-fluorenylmethoxycarbonyl (Fmoc) protection at C-2 have been described. The Toac analogues were synthesized as part of a study of the crystal structure and ab initio calculations for these interesting systems. 

In the presence of 4-amino-2,2,6,6-tetramethyl-piperidine, a partial nucleophilic substitution of the bromine atom occured it resulted in the formation of a new polymeric stabilizer which has been treated by peracetic acid vapor. 

Piperidin 4-(Aziridino-thiocarbonyl-amino)-l-oxi-2,2,6,6- tetramethyl-E4, 487 (R-NCS + Amin)... 

Victor KG, Cafiso DS. Location and dynamics of basic peptides at the membrane interface electron paramagnetic resonance spectroscopy of tetramethyl-piperidine-N-oxyl-4-amino-4-carboxylic acid-labeled peptides. Biophys. J. 2001 81 2241-2250. 

Interesting stabilizers were obtained by functionalization of poly(maleic anhy-dride-co-a-methylstyrene) or epoxidized PP with 4-amino-2,2,6,6-tetramethyl-piperidine [296], Maleic anhydride grafted PP, EPDM and SAN or polyacrylates with pending anhydride or epoxy groups were functionalized with N-(2,2,6,6-tetramethyl-4-piperidyl)-/V-aminooxamide 192 [297]. Polymer of the type 193 containing HAS moiety is an example. 

An alternative strategy for the introduction of spin labels can be used in protein and peptide chemistry by spin label building blocks, e.g., 4-amino-l-oxyl-2,2,6,6-tetramethyl-piperidine-4-carboxylic acid (TOAC, Fig. 1, right) which are directly incorporated into the peptide during chemical synthesis [20-25]. 

Chemical name poly[[6-[(1,1,3,3-tetramethylbutyl) amino]-1,3,5-triazine-2,4-diyl] [(2,2,6,6-tetramethyl-4-piperidinyl) imino]-1,6-hexanediyl[(2,2,6,6-tetra-methyl-4-piperidinyl)imino]]) + butane-dioic acid, dimethylester, polymer with 4-hydroxy-2,2,6,6-tetramethyl-1-piperidine ethanol ... 

Aminomethyl-3-ithyl-piperidin 22 1 624. Bei 25— 26° schmelzendea 4-Amino-2.2.6-toimetliyl-piperidin 22, 421,1624, II 320, FIttssises 4-Amino-2.2.6-trimethyl-piperidin 22, 422,1626. II320. 3-Ai o-2.2.5.5-tetramethyl-pyTtoIidiD 22 422. 

Fig. 1. A nitroxide that is commonly used in polymer spin labeling based on the commercially available 4-amino-2,2,6,6-tetramethyl piperidine-1-oxyl (TEMPAMINE) radical.

Stabilizers UVA 2-hydroxy-4-octyloxybenzophenone 2-(2H-benzo-triazol-2-yl)-6-dodecyl-4-methylphenol, branched linear propanedioic acid, [(4-methoxyphenyl)-methylene]-dimethyl ester HAS 1,3,5-triazine-2,4,6-triamine, N,N [1,2-ethane-diyl-bis[[[4,6-bis[butyl(1,2,6,6-pentamethyl-4-piperidinyl) amino]-1,3,5-triazine-2-yl]imino]-3,1 -propanediyl]bis[N, N -dibutyl-N ,N -bis(1,2,2,6,6-pentamethyl-4-piperidinyl)- poly[[(6-[1,1,3,3-tetramethylbutyl)amino]-1,3,5-triazine-2,4-diyl] [2,2,6,6-tetramethyl-4-piperidinyl)imino]-1,6-hexanediyl[2,2,6,6-tetramethyl-4-piperidinyl)imino]] 1,6-hexanediamine- N,N -bis(2,2,6,6-tetramethyl-4-piperidinyl)-polymer with 2,4,6-trichlo-ro-1,3,5-triazine, reaction products with N-butyl-1-butanamine an N-butyl-2,2,6,6-tetramethyl-4-piperidinamine butanedioic acid, dimethylester, polymer with 4-hydroxy-2,2,6,6-tetrameth-yl-1-piperidine ethanol Phenolic antioxidant pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) Amine benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene Optical brightener 2,2 -(1,2-ethyl-enediyldi-4,1-phenylene)bisbenzoxazole, C.I.F.B. 367 ... 

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