Pig striatum

Fornstedt, B., Carlsson, A. A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment. J. Neural Transm. 76 155, 1989. 

Shiomi H, Kuraishi Y, UedaH, Harada Y, Amano H, Takagi H (1981) Mechanism of kyotorphin-induced release of Met-enkephalin from guinea pig striatum and spinal cord. Brain Res 221 161-169... 

Fomstedt, B. Pilebad, E. and Carlsson, A. In vivo autoxidation of dopamine in guinea-pig striatum increases with age. JNeurochem 55 655-659, 1990. 

Fornstedt, B. and Carlsson, A (1991b) Vitamin C deficiency facilitates 5-S-cysteinyldopamine formation in guinea pig striatum. J. Neurochem. 56 407-414. 

Affinities of various compounds that compete for 0.1 nM [ H]-GR 113808 in homogenates of colliculi neurons [125], human striatum [56] and guinea-pig striatum [55,56]. 

Cyclic AMP stimnlation - in vitro (guinea pig, striatum) at 100.0 pM vs. forskolin-stimulated camp level. Diltiazem binding inhilHtion - in vitro (rat, membrane-cerebral cortex) at 26.3 pM. 

Localization CNS Hippocampus (CA1, CA3, DG), septum, amygdala, raphe nuclei CNS Striatum, hippocampus (CA1), substantia nigra, globus pallidus, superior colliculi, spinal cord, raphe nuclei CNS like 5-HT1B but at lower densities. CNS Caudate putamen, parietal cortex, fronto-parietal motor cortex, olfactory tubercle, amygdala CNS Cortex, Thalamus, olfactory bulb (rat), claustrum (g-pig), hippocampus (CA3), spinal cord. 

Lapchak PA, Araujo DM, Collier B. (1989). Regulation of endogenous acetylcholine release from mammalian brain slices by opiate receptors hippocampus, striatum, and cerebral cortex of guinea-pig and rat. Neuroscience. 31(2) 313-25. 

Fig. 1. Occurrence of H3 receptors inhibiting release of acetylcholine, of amino acid and monoamine neurotransmitters in the mammalian CNS in vitro. The schematic drawing represents a midsagittal section of the human brain three areas with a more lateral position are shown by broken line (substantia nigra and part of the hippocampus and of the striatum). For each of the six regions of the CNS (subregions given in brackets), in which H3 heteroreceptors have been identified, the neurotransmitter(s) and the species are indicated. The superscripts refer to the numbers of the papers as listed under References. Own unpublished data suggest that an H3 receptor-mediated inhibition of noradrenaline release also occurs in the human cerebral cortex and hippocampus and in the guinea-pig cerebral cortex. Note that a presynaptic location has not been verified for each of the H3 heteroreceptors or has been even excluded (for details, see Table 1). Abbreviations ACh, acetylcholine DA, dopamine GABA, y-aminobutyric acid Glu, glutamate 5-HT, 5-hydroxytryptamine, serotonin NA, noradrenaline...

Foetal mesencephalic tissue has been implanted in the striatum of patients with the juvenile form of Parkinson s disease and has been shown to develop functional axons this has enabled the dose of L-dopa to be reduced. Both imaging and pharmacological studies have now shown that functional dopaminergic neurons can develop in the brain of the patient following tissue transplantation. However, a major ethical objection has been raised to such transplants as six to seven foetal brains are required to obtain sufficient tissue. In addition, only about 20% of neurons survive transplantation. The ethical problem may be overcome by using brain transplants from domestic animals such as pigs. Such xenotransplants have been shown to survive in the human brain but the main problem with the extensive use of such transplants is the possible spread of viruses and prion infections. 

The first distribution studies of the 5-HT1F receptors involved the localization of its mRNA by in situ hybridization histochemistry in the mouse (82), rat (83), and guinea pig (14,75) brains. 5-HT1F receptor mRNA is found in layer V of cortex, claustrum, striatum, several thalamic nuclei, hippocampus, some nuclei of the amygdala, and in the dorsal raphe. There are no reports on the localization of 5-HT1F receptor mRNA in human brain by in situ hybridization histochemistry. 

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