Picolyl chloride hydrochloride

The side chain hydroxy group of 3-(2-hydroxyethyl)-2-methyl-9-methoxy-4//-pyrido[l,2-u]pyrimidin-4-one, and that of its 6,7,8,9-tetrahydro derivative was acylated with MeS02Cl in the presence of NEts in CH2CI2 at room temperature (95MIP4, 96MIP2). The hydroxy group of 2-[4-(4-hydro-xybenzoyl)benzyloxy]-3-methyl-4//-pyrido[l, 2-u]-pyrimidin-4-one, its 6-methyl derivative and 2-[4-(4-hydroxybenzoyl)benzylthio]-3-methyl-4//-pyrido[l, 2-u]pyrimidin-4-one was alkylated with 4-(2-chloroethyl)morpholine hydrochloride and 4-picolyl chloride hydrochloride (96EUP733633). 

Picolyl chloride hydrochloride Picric acid (2,4,6-Trinitrophenol)... 

Picolyl chloride hydrochloride Promethazine hydrochloride Tetramethylammonium hydroxide Xylenesulfonic acid sodium salt Chemical Warfare Agents Lewisite (Agent L)... 

PEPTIDE SYNTHESIS Diphenylphosphoryl azide. N-Ethoxycarbonyl-2-ethoxy-l,3-di-hydroquinoline. o-Nitrophenylsulfenyl chloride. 2-Picolyl chloride hydrochloride. Silicon tetrachloride. Triphenylpbosphine. Triphcnylphosphinc-Carbon tetrachloride. Triphcnyl phosphite. 

Picolyl ethers are prepared from their chlorides by a Williamson ether synthesis (68-83% yield). Some selectivity for primary versus secondary alcohols can be achieved (ratios = 4.3-4.6 1). They are cleaved electrolytically ( — 1.4 V, 0.5 M HBF4, MeOH, 70% yield). Since picolyl chlorides are unstable as the free base, they must be generated from the hydrochloride prior to use. These derivatives are relatively stable to acid (CF3CO2H, HF/anisole). Cleavage can also be effected by hydrogenolysis in acetic acid. ... 

THIOL GROUPS 2-Picolyl chloride 1-oxide hydrochloride. (3-Nitro-styrene. 

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