Physicochemical Properties and Reactivity

Most of the available data are found in the experimental sections of the original preparative work, giving the standard IR, UV, and NMR spectral data. To date no systematic study of the physical properties have been undertaken, nor have any measurements of theoretical interest been carried out, such as photoelectron emission, mass spectrometry, and electrochemical determinations. 

Since most of these compounds have only recently been prepared, there has been little time to study their chemical behavior. 

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In this section, only salient features of the synthesis, physicochemical properties, and reactivity of major derivatives of 2-aminothiazole and 2-imino-4-thiazoline are summarized. Further details on each compound are found in associated references collected in Section VII. The synthetic methods reported in this section exclude heterocydization methods treated in Chapter II but given in specific references found in Section VII. 

Tetrahydropyridines. 12, 43 Tetra/.ole chemistry, recent advances in. 21, 323 Theoretical studies of physicochemical properties and reactivity of azines, 5, 69... 

Methodologies based on fragment descriptors in QSAR/QSPR studies are not strictly confined to particular types of properties or compounds. In the 1970s Adamson and coworkers" " were the first to apply fragment descriptors in multiple linear regression analysis to find correlations with some biological activities,physicochemical properties, and reactivity. ... 

The problems associated with freeze drying of peptides and proteins for therapeutic use have also received calorimetric attention recently - particularly, attempts to understand and interpret the dynamics of amorphous solids. Structural relaxation time is a measure of molecular mobility involved in enthalpy relaxation and thus is a measure of the dynamics of amorphous (glassy) solids. These dynamics are important in interpretation of the physicochemical properties and reactivities of drugs in amorphous formulations. The authors conclude that microcalorimetry may provide data useful for rational development of stable peptide and protein formulations and for control of their processing . 

Theoretical Studies of Physicochemical Properties and Reactivity of Azines P ... 

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