Physalis angulata, physalin

Makino B, Kawai M, Ogura T, Nakanishi M, Yamamura H, Butsugan Y (1995) Structural Revision of Physalin H Isolated from Physalis angulata. J Nat Prod 58 1668... 

Ubiquitin-proteasome pathway, involved in the degradation of tumor growth proteins, plays an important role in the treatment of cancer. Physalin B (6), the major steroidal lactone of Physalis angulata, is known to produce the ubiquitinated protein accumulation and inhibit the TNFa-induced activation of NF-KB in DLD-1 4Ub-Luc cell assay. Physalin B does not inhibit purified proteasome catalytic activities but interferes with the cellular catalytic activities of the proteasome proteins at 4—8-fold high concentration, which is required to produce significant rise in bioluminescence and ubiquitinated protein accumulation in DLD-1 4Ub-Luc cells. The results indicate that physalin B is cytotoxic and works as an apoptotic triggering agent in DLD-1 4Ub-Luc cells [95]. 

Row LR, Sarma NS, Reddy KS, Matsuura T, Nakashima R (1978) The structnre of physalins F and J from Physalis angulata and Physalis lancifolia. Phytochtanistry 17 1647-1650... 

Januario AH, Filho ER, Pietro RC, Kashima S, Sato DN, Franea SC (2002) Antimyeo-bacterial physalins from physalis angulata L. (solanaceae). Phytother Res 16 445-448... 

Damn AG, Kuo PC, Su CR, Kho TH, Chen TH, Bastow KF, Lee KH, Wu TS (2007) Isolation, structures and Structure-cytotoxicity activity relationships of withanolides and physalins from Physalis angulata. J Nat Prod 70 1146-1152... 

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