Physalis angulata

Soares MB, Bellintani MC, Ribeiro IM, Tomassini TC, Ribeiro dos Santos R. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. Eur J Pharmacol 2003 459 107-112. 

Ismail, N. and Alam, M., A novel cytotoxic flavonoid glycoside from Physalis angulata, Fitoter-apia, 72, 676, 2001. 

Physalis angulata L. Ku Zhi (Groundcherry) (fruit, leaf) Hystonin.60 Overdose may cause dizziness. Antifebrile, laxative, diuretic, causing uterine contractions. 

Makino B, Kawai M, Ogura T, Nakanishi M, Yamamura H, Butsugan Y (1995) Structural Revision of Physalin H Isolated from Physalis angulata. J Nat Prod 58 1668... 

Physalis angulata L. - camapu Nerve diseases Root (tea, ingested) Caboclos [56] Steroids [215,216] flavonoids [217] alkaloids [218] ... 

Very recently physagulin C epoxide) isolated by Shingu et al. from Physalis angulata L. 

A series of ten withanolides, isolated from Physalis minima, were evaluated for their cytotoxic properties against HCT-116 and NCI-H460 cell lines. It was found that withaphysalin C (31) was active against both the cell lines [72]. The stmcture-activity relationship (SAR) studies of the C3dotoxic withanolides from Physalis minima and Physalis angulata indicate that the a,)S-unsaturated ketone moiety in ring A and 5jS-6/i oxirane moiety in ring B are important contributors in the cytotoxicity of withanolides. The absence of these two structural features may result in a loss or reduction of the cytotoxicity of withanohde [4]. 

Ubiquitin-proteasome pathway, involved in the degradation of tumor growth proteins, plays an important role in the treatment of cancer. Physalin B (6), the major steroidal lactone of Physalis angulata, is known to produce the ubiquitinated protein accumulation and inhibit the TNFa-induced activation of NF-KB in DLD-1 4Ub-Luc cell assay. Physalin B does not inhibit purified proteasome catalytic activities but interferes with the cellular catalytic activities of the proteasome proteins at 4—8-fold high concentration, which is required to produce significant rise in bioluminescence and ubiquitinated protein accumulation in DLD-1 4Ub-Luc cells. The results indicate that physalin B is cytotoxic and works as an apoptotic triggering agent in DLD-1 4Ub-Luc cells [95]. 

Row LR, Sarma NS, Reddy KS, Matsuura T, Nakashima R (1978) The structnre of physalins F and J from Physalis angulata and Physalis lancifolia. Phytochtanistry 17 1647-1650... 

Januario AH, Filho ER, Pietro RC, Kashima S, Sato DN, Franea SC (2002) Antimyeo-bacterial physalins from physalis angulata L. (solanaceae). Phytother Res 16 445-448... 

Damn AG, Kuo PC, Su CR, Kho TH, Chen TH, Bastow KF, Lee KH, Wu TS (2007) Isolation, structures and Structure-cytotoxicity activity relationships of withanolides and physalins from Physalis angulata. J Nat Prod 70 1146-1152... 

Abdel-Gwad MM, El-Amin SM, El-Sayed MM, Refahy LA, Sabry WA (1997) MoUusddal saponins from Cestrum parqui. Al-Azar J Pharmaceut Sci 20 80-84 Abe F, Nagafuji S, Okawa M, Kinjo J (2006) Trypanocidal constituents in plants 6. Minor with-anoUdes from the aerial parts of Physalis angulata. Chem Pharm BuU 54 1226-1228... 

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