Phosphoryl sulphoxides synthesis

Oxidation of phenyl hexyl sulphide with sodium metaperiodate gave also only a trace amount of the corresponding sulphoxide72. On the other hand, Hall and coworkers73 prepared benzylpenicillin and phenoxymethyl penicillin sulphoxides from the corresponding benzyl esters by oxidation with sodium metaperiodate in dioxane solution with a phosphate buffer. A general procedure for the synthesis of penicillin sulphoxides was reported later by Essery and coworkers74 which consists in the direct oxidation of penicillins or their salts with sodium metaperiodate in aqueous solution at pH 6.5-7.0. 1-Butadienyl phenyl sulphoxide 4475 and a-phosphoryl sulphoxides 4576 were also prepared by the same procedure. 

TABLE 24. Synthesis of vinyl sulphoxides 443 from a-phosphoryl sulphoxides 442... 

Phosphorylation 341, 342 Phosphoryl sulphoxides reactions of 333, 825 synthesis of 70, 246, 341, 342 Photochemical oxidation 877, 878 Photoelectron spectroscopy, of... 

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See also in sourсe #XX -- [ , , , ]

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