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Toxicology phosphorothioate oligonucleotides

Henry SP Bolte H, Auletta C, Komburst DJ. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four week study in cynomolgus monkeys. Toxicology 1997 120 145-155. [Pg.379]

In conclusion, phosphorothioate oligonucleotides may interact with a wide range of proteins through several types of mechanisms. These interactions may influence the pharmacokinetic, pharmacologic, and toxicologic properties of these molecules. They may also complicate studies on the mechanism of action of these drugs, and may obscure an antisense activity. For example, phosphorothio-... [Pg.131]

Srinivasan SK, Iversen P (1995) Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides. J Clin Lab Anal 9(2) 129-137... [Pg.58]

Levin, A.A. 1999. A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta 1489 69-84. [Pg.266]

See other pages where Toxicology phosphorothioate oligonucleotides is mentioned: [Pg.540]    [Pg.322]    [Pg.352]    [Pg.335]    [Pg.143]    [Pg.314]    [Pg.42]   
See also in sourсe #XX -- [ Pg.2 , Pg.139 , Pg.140 , Pg.141 ]

See also in sourсe #XX -- [ Pg.139 , Pg.140 , Pg.141 ]



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