Phosphonic acid difluoro ester

Dialkyl (bromodifluoromethyl)phosphonates react with zinc dust at room temperature to give products which may be acylated (Scheme 3). (Difluoro-methylene)bis(phosphonic acid) has been prepared by the hydrolysis of its tetrakis(trimethylsilyl) ester its sodium salts are stable to strong alkali. Scheme 4 outlines a synthesis, starting from the anion of monofluoromethylenebis-(phosphonic acid) tetraisopropyl ester, of (l-fluoroethenyl)phosphonates, hydrogenation of which gives (l-fluoroalkyl)phosphonates. ... 

Alternate Names phosphonic acid, [difluoro(methylthio)-methyl]-, bis(l-methylethyl) ester. 

Esters of (2,2-difluoro-3,4-dihydroxybutyl)phosphonic acid have been obtained through an epoxide ring-opening reaction ", and such a procedure has also been successfully applied to the preparation of mono-, di- and tri-hydroxy acids depending on the nature of the oxirane substituents (reaction 13)(X , = CH2Ph or / -toluenesulphonyl, or... 

Abramov nucleophilic addition of various phosphorus acid esters to nucleoside aldehyde derivatives yielded the phosphonate-based iso-polar, non-iso-steric 5 -nucleotide analogues (28) containing a geminal hydroxy phosphonate moiety on the 5 -carbon of the pentofuranose ring. The enantiomerically pure D- and l- 2, 3, 5 -trideoxy-4 -[(ethoxyphosphoryl) difluoromethyl] thymidine analogues(29) have been synthesized from (i 5)-( )-2-methyl-5-(4-methyl-phenyl-sulfinyl)pent-2-ene and ethyl 2-(diethoxyphosphoryl)-2,2-difluoro-acetate in 45% overall yield over seven steps. ... 

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