Zincated phosphonate

SYNTHESIS, STRUCTURE AND PROTECTIVE PROPERTIES OE TETRA SODIUM NITRILO-TRIS-METHYLENE PHOSPHONATE ZINCATE TRIDECAHYDRATE Na [N(CH2 P03)3 Zn]x13Hp... 

Synthesis, stmcture and protective properties of tetra sodium nitrile-tris-methylene phosphonate zincate tridecahydrate Na4[N(CH2P03)3Zn]-13Hp... 

A direct approach to a-amino phosphonic acids derivatives (594) has been developed by McDonald and Wang. Thus, copper-catalysed electrophilic amination of a-phosphonate zincates (592) with O-acyl hydro-xylamines (593) (Scheme 172) provided the first example of C-N bond formation which directly introduced acyclic and cyclic amines (592) to the a-position of phosphonates (591) in one step. ° ... 

Copper catalysed addition of a (3-zincated phosphonate to an electrophile preparation of dimethyl 2-(cyclohex-1-en-3-on-1-yUpentanephosphonate10... 

Dibromo-2,2 -bisbenzimidazoles 692 react with aryl zincates under Negishi coupling conditions to give 4,4 -bisaryl-2,2 -bisbenzimidazoles 693 (Scheme 168). Lower yields were obtained with heteroaryl zincates (2- or 3-pyridyl) <2006OL4989>. Cross-coupling of bromides 694 with phosphonites provided an efficient synthesis of phosphonates 695 <1998TL2797>. 

Substitution reactions of zinc or zinc-copper organometallics with RaSiCl are usually difficult, whereas tin reagents of t3T>e RsSnCl react more eflBciently. Thus, the -zincated phosphonate 347 provides imder mild conditions the stannylated product 348 in 81% yield " (Scheme 2-118). 

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