Copper-catalysed DKR

In order to explain this DKR, it was proposed that a copper enolate intermediate was formed on asymmetric conjugate reduction of the enone. Subsequent a-bond metathesis with silane yielded the silyl enol ether and regenerated the copper hydride catalyst. Under basic conditions, a rapid 

In 2005, the same group reported the first total synthesis of eupomatilone-3, on the basis of a DKR of a a,/l-unsaturated butenolide submitted to an asymmetric 

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In 2002, Jurkauskas and Buchwald reported the copper-catalysed DKR of 3,5-dialkylcyclopentenones, employing catalytic (5)-p-tol-BINAP/CuCl/NaOt-Bu and poly(methylhydrosiloxane) as a stoichiometric reductant." This process was a unique approach to simultaneously establish two nonadjacent stereocentres in dialkylcyclopentanones (Scheme 2.78). 

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