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Amphiphiles phospholipid analogues

The immunomodulatory azaspiranes are novel cationic amphiphilic drugs with beneficial effects in a number of animal models of autoimmune disease and transplantation. Waites et al. (1995) compared W,W-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine HCl (SK F 105685) and two analogues, SK F 106615 and SK F 103811 with chlor-phentermine and chloroquine for their ability to induce phospholipid accumulation and suppressor cell activity. Oral administration of SK F 105685 and SK F 106615 caused phospholipid accumulation in bronchoalveolar lavaged rat macrophages but to a far lesser extent (three- to fivefold) than chlorphentermine. Neither the immunologically unreactive azaspirane SK F 103811 nor chloroquine affected phospholipid levels. Alveolar macrophages from rats treated with SK F 105685 or SK F 106615 expressed more potent suppressor cell activity than chlorphentermine. Neither SK F 103811 nor chloroquine induced suppressor cell activity. [Pg.285]

See other pages where Amphiphiles phospholipid analogues is mentioned: [Pg.131]    [Pg.133]    [Pg.133]    [Pg.128]    [Pg.103]    [Pg.128]    [Pg.44]    [Pg.622]    [Pg.88]    [Pg.97]    [Pg.212]    [Pg.115]    [Pg.861]    [Pg.301]   
See also in sourсe #XX -- [ Pg.131 , Pg.132 , Pg.133 ]



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