Phospholipid analogs

Hendrickson, H. S., Hendrickson, E. K., Johnson, I. D. and Farber, S. A. (1999). Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. Anal. Biochem. 276, 27-35. 

The dynamics of lipid movement between the two leaflets of membrane lipid bilayers has been monitored using a variety of phospholipid analogs. Most of the analogs incorporate a reporter group attached to the C-2 of the glycerol moiety. One common substituent is a florescent-labelled fatty acid to form 1,2-(palmitoyl-N-4-nitrobenzo-2-oxa-1,3-diazole-amino-caproyl)... 

Gadella, B.M., Miller, N.G., Colenbrander, B., van Golde, L.M. and Harrison, R, A. 1999, Flow cytometric detection of transbUayer movement of florescent phospholipid analogs across the boar sperm plasma membrane elimination of labeling artifacts. Mol. Reprod. Dev.53 108-125. 

Geilen, C.C., Haase, A., Wieder, T., Arndt, D., Zeisig R. and Reutter W., 1994, Phospholipid analogs side chain- and polar head group-dependent effects on phosphatidylcholine biosynthesis. J. Lipid Res. 35 625-632... 

Hub HH, HupferB, Koch H, Ringsdorf H. Polyreactions in ordered systems. 20. Polymerizable phospholipid analogs—new stable biomembrane and cell models. Angew Chem Int Ed... 

Ether phospholipids, analogous to the ether lipids described in Section 2, are also widely distributed. Tire alkenyl ether analogs of phosphatidylcholine (Fig. 8-2) are called plasmalogens.17 In neutrophils the 1-O-alkyl ethers contain the major share of the cell s arachidonic acid, which is esterified in the 2 position.1819... 

Andresen T. L. and Jorgensen K. (2005). Synthesis and membrane behavior of a new class of unnatural phospholipid analogs useful as phospholipase A2 degradable liposomal drug carriers. Biochim. Biophys. Acta Biomembr. 1669 1-7. 

A simple hydrophobic reagent is a small radiolabeled organic molecule that can be photochemically activated after it has bound to a lipid bilayer. The major merit of such reagents in comparison to phospholipid analogs is that they are simple to use with native membranes. Klip and Gitler (1974)... 

Korematsu A, Takemoto Y, Nakaya T, Inoue H. Synthesis, characterization and platelet adhesion of segmented polyurethanes grafted phospholipid analogous vinyl monomer on surface. Biomaterials 2002 23 263-71. 

The polymerization behavior of Schemes (81a), (81b) and (81c) is similar to that of unsubstituted monomers [384]. Copolymers of Schemes (81a), (81b) and (81c) with 1,3-butadiene [427], acrylonitrile [428], acryl ester [426], and styrene [426] are of technical interest, due to their fire-retarding properties. Detailed investigations are available on monomers of type (81a), which are particular interesting as models for phospholipide-analogous biological membranes [429]. Table 9 shows selected structure variations of those monomers. 

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