Phosphofructokinase in muscle

Type VII Tarul s disease Deficiency of phosphofructokinase in muscle and erythrocytes As for type V but also possibility of hemolytic anemia. 

Krebs and Woodford (72) have reported the activity of FDPase to be much lower than that of phosphofructokinase in muscle, but it has been estimated by Salas et al. (71) that in view of the relative mass of muscle tissue, the total FDPase activity of muscle was equivalent to that of liver. It was proposed by Krebs and Woodford (72) that the enzyme might play a role in the reconversion of a-glycerophosphate to carbohydrate since this substance was found to accumulate in significant quantities in muscle. This hypothesis has been examined in detail by... 

Explain how a defect in phosphofructokinase in muscle can lead to increased amounts of glycogen having a normal structure. Patients with this defect are normal except for having a limited ability to perform strenuous exercise. 

The discussions in the previous section have outlined the basic principles involved in the generation and control of a steady-state flux. However, the situation in vivo is usually much more complex. First, there may be several regulators interacting with each other [as in the control of 6-phosphofructokinase in muscle (35)]. Second, mechanisms designed to increase the strength of the response of the flux to a change in concentra-... 

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See also in sourсe #XX -- [ , ]

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